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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2002 3
2003 5
2004 6
2005 2
2006 7
2007 3
2008 1
2009 3
2010 4
2011 5
2012 3
2013 6
2014 4
2015 3
2016 4
2017 3
2018 3
2019 4
2020 2
2021 4
2022 3
2023 8
2024 2

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81 results

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Page 1
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation.
Wang J, Xie W, Li N, Li W, Zhang Z, Fan N, Ouyang Z, Zhao Y, Lai C, Li H, Chen M, Quan L, Li Y, Jiang Y, Jia W, Fu L, Mazid MA, Zhu Y, Maxwell PH, Pan G, Esteban MA, Dai Z, Lai L. Wang J, et al. Cell Stem Cell. 2023 Sep 7;30(9):1235-1245.e6. doi: 10.1016/j.stem.2023.08.003. Cell Stem Cell. 2023. PMID: 37683604
The resulting cells had substantially enhanced viability in the xeno-environment of interspecies chimeric blastocyst and successfully formed organized human-pig chimeric middle-stage kidney (mesonephros) structures up to embryonic day 28 inside nephric-defective pig embryo …
The resulting cells had substantially enhanced viability in the xeno-environment of interspecies chimeric blastocyst and successfully formed …
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
Gadd S, Huff V, Walz AL, Ooms AHAG, Armstrong AE, Gerhard DS, Smith MA, Auvil JMG, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Hermida LC, Davidsen T, Gesuwan P, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Dome JS, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Ross N, Gastier-Foster JM, Arold ST, Perlman EJ. Gadd S, et al. Nat Genet. 2017 Oct;49(10):1487-1494. doi: 10.1038/ng.3940. Epub 2017 Aug 21. Nat Genet. 2017. PMID: 28825729 Free PMC article.
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR …
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, …
Prioritization of Monogenic Congenital Anomalies of the Kidney and Urinary Tract Candidate Genes with Existing Single-Cell Transcriptomics Data of the Human Fetal Kidney.
Schierbaum LM, Schneider S, Buerger F, Halawi AA, Seltzsam S, Wang C, Zheng B, Wu CW, Dai R, Connaughton DM, Salmanullah D, Nakayama M, Mann N, Shril S, Hildebrandt F. Schierbaum LM, et al. Nephron. 2023;147(11):685-692. doi: 10.1159/000531770. Epub 2023 Jul 27. Nephron. 2023. PMID: 37499630 Free PMC article.
INTRODUCTION: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in the first 3 decades of life. ...A maximum of high expression in consecutive timepoints of kidney development was found for four o …
INTRODUCTION: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease …
SIX1 gene: absence of mutations in children with isolated congenital anomalies of kidney and urinary tract.
Negrisolo S, Centi S, Benetti E, Ghirardo G, Della Vella M, Murer L, Artifoni L. Negrisolo S, et al. J Nephrol. 2014 Dec;27(6):667-71. doi: 10.1007/s40620-014-0112-x. Epub 2014 Jun 5. J Nephrol. 2014. PMID: 24899122
BACKGROUND: Mutations in human SIX1 gene cause branchiootorenal or branchiootic syndrome. Six1 deficient mice exhibit uni- or bilateral renal hypoplasia or kidney agenesis. ...Nevertheless, further studies are necessary to understand if altered SIX1 ex …
BACKGROUND: Mutations in human SIX1 gene cause branchiootorenal or branchiootic syndrome. Six1 deficient mice exhibit uni- or …
Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation.
Xu J, Li J, Ramakrishnan A, Yan H, Shen L, Xu PX. Xu J, et al. Front Cell Dev Biol. 2022 Feb 1;10:815249. doi: 10.3389/fcell.2022.815249. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35178390 Free PMC article.
Both genes are expressed in nephron progenitors of human fetal kidneys, and mutations in SIX1 or SIX2 cause branchio-oto-renal syndrome or renal hypodysplasia respectively. ...Altogether, these data indicate that Six1 cannot substitute Six2 to drive nephrogen …
Both genes are expressed in nephron progenitors of human fetal kidneys, and mutations in SIX1 or SIX2 cause branchio-oto-renal …
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
Yan B, Neilson KM, Ranganathan R, Maynard T, Streit A, Moody SA. Yan B, et al. Dev Dyn. 2015 Feb;244(2):181-210. doi: 10.1002/dvdy.24229. Epub 2014 Dec 16. Dev Dyn. 2015. PMID: 25403746 Free PMC article.
BACKGROUND: Six1 plays an important role in the development of several vertebrate organs, including cranial sensory placodes, somites, and kidney. ...RESULTS: We sought to identify novel genes expressed during placode, somite and kidney development by compari …
BACKGROUND: Six1 plays an important role in the development of several vertebrate organs, including cranial sensory placodes, somites …
Retinal determination gene networks: from biological functions to therapeutic strategies.
Zhu S, Li W, Zhang H, Yan Y, Mei Q, Wu K. Zhu S, et al. Biomark Res. 2023 Feb 8;11(1):18. doi: 10.1186/s40364-023-00459-8. Biomark Res. 2023. PMID: 36750914 Free PMC article. Review.
Additionally, we discuss the roles of RDGN members in the development of organs and tissue as well as their correlations with the pathogenesis of chronic kidney disease and coronary heart disease. By summarizing the roles of RDGN members in human diseases, we hope to promo …
Additionally, we discuss the roles of RDGN members in the development of organs and tissue as well as their correlations with the pathogenes …
Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R. Fujimoto Y, et al. Dev Cell. 2013 Aug 26;26(4):416-30. doi: 10.1016/j.devcel.2013.06.018. Dev Cell. 2013. PMID: 23987514 Free article.
The Y-linked gene Sry regulates mammalian sex determination in bipotential embryonic gonads. Here, we report that the transcription factors Six1 and Six4 are required for male gonadal differentiation. Loss of Six1 and Six4 together, but neither alone, resulted in a …
The Y-linked gene Sry regulates mammalian sex determination in bipotential embryonic gonads. Here, we report that the transcription factors …
Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers.
Chow T, Wong FTM, Monetti C, Nagy A, Cox B, Rogers IM. Chow T, et al. NPJ Regen Med. 2020 Apr 20;5:7. doi: 10.1038/s41536-020-0092-5. eCollection 2020. NPJ Regen Med. 2020. PMID: 32351711 Free PMC article.
Aggregated renal progenitors gave rise to organoids consisting of LTL+/E-cadherin+ proximal tubules, cytokeratin+ ureteric bud-derived tubules, and extracellular matrix proteins secreted by the cells themselves. Over-expression of key kidney developmental genes, Pax2, S …
Aggregated renal progenitors gave rise to organoids consisting of LTL+/E-cadherin+ proximal tubules, cytokeratin+ ureteric bud-derived tubul …
Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9-mediated SIX1 and SIX4 gene targeting.
Wang J, Liu M, Zhao L, Li Y, Zhang M, Jin Y, Xiong Q, Liu X, Zhang L, Jiang H, Chen Q, Wang C, You Z, Yang H, Cao C, Dai Y, Li R. Wang J, et al. Xenotransplantation. 2019 May;26(3):e12484. doi: 10.1111/xen.12484. Epub 2019 Jan 9. Xenotransplantation. 2019. PMID: 30623494
SIX1 and SIX4 genes play critical roles in kidney development. We evaluated the effect of these genes on pig kidney development by generating SIX1(-/-) and SIX1(-/-) /SIX4(-/-) pig foetuses using CRISPR/Cas9 and somatic cell nuclear transfer. .. …
SIX1 and SIX4 genes play critical roles in kidney development. We evaluated the effect of these genes on pig kidney dev …
81 results